Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility
نویسندگان
چکیده
منابع مشابه
Rapamycin prolongs female reproductive lifespan
www.landesbioscience.com Cell Cycle 3353 The pool of ovarian primordial follicles is established during embryonic development in humans, or after birth in rodents, and serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. Once the pool of primordial follicles has been exhausted, menopause occurs in women around 50 y old. With modern...
متن کاملFood restriction during pregnancy and female offspring fertility: adverse effects of reprogrammed reproductive lifespan
BACKGROUND Food restriction during pregnancy can influence the health of the offspring during the adulthood. The aim of the present study was to examine the effect of maternal food restriction (MFR) on the reproductive performance in female rat offspring from the first (FR1) and second (FR2) generations. METHODS Adult virgin Wistar female rats were given free access to tap water and were fed ...
متن کاملFemale post-reproductive lifespan: a general mammalian trait.
Traditional explanations for the evolution of menopause and post-reproductive lifespan in human females have been based on the benefits of maternal or grand-maternal care outweighing the cost of lost reproduction. These explanations assume an evolutionary origin of menopause since human divergence with the most recent common ancestor. In this study, I conduct a literature survey of studies of 4...
متن کاملGenetic Evaluation for Female Fertility in Switzerland
In Switzerland, infertility is the main reason for involuntary culling of dairy cows. According to several studies, 25 to 35 % of dairy cows are culled because of reproductive problems (Rust, 2001; Aeberhard et al., 1997; Stärk et al., 1997). Failure to conceive, absent or unobservable cyclicity and embryonic loss are the most important culling reasons within the “reproductive problems”-complex...
متن کاملRethinking progesterone regulation of female reproductive cyclicity.
The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in the regulation of female fertility. Much has been learned of the actions of PGR signaling through the use of pharmacologic inhibitors and genetic manipulation, using mouse mutagenesis. Characterization of rats with a null mutation at the Pgr locus has forced a reexamination of the role of progesterone i...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22052556